B. Sc. III  Curriculum (Theory) Semester -VI

B. Sc. III (Theory)

Semester -VI

Paper XIX

(Genetics and Biotechnology)

(45 L)

Unit : 1

1. Mendelism:                                                                                                                         (04)

i. Introduction -G.J. Mendel

ii. Mendelian principles –Law of Dominance , law of segregation, law of

independent assortment, back cross and test cross

2. Interaction of genes:                                                                                                           (07)

i. Allelic interaction: incomplete dominance, co dominance, lethal genes and blood group inheritance

ii. Non allelic and non epistatic -comb shapes in fowls

iii. Non allelic and epistatic:

a) Complementary genes or duplicate recessive epistasis (9:7)

b) Supplementary genes or recessive epistasis (9:3:4)

c) Dominant epistatic genes or dominant epistasis (12:3:1)

d) Duplicate genes or duplicate dominant epistasis (15:1)

3. Sex determination:                                                                                                              (04)

i. Chromosomal theory of sex determination

ii. Mechanism of sex determination in man (xx -xy), Drosophila (xx and xy),birds (zz-zw), grasshopper (xx-xo) and genic balance theory in Drosophila

iii. Sex determination in plants – Melandrium

Unit : 2

1. Sex linked inheritance: X, XY and Y linked inheritance:                                                  (07)

i) Colourblindness and hemophilia in man ii) Holandric genes

iii) White eye colour in Drosophila iv) Gynandromorphs

2. Structure and function of gene:                                                                                          (08)

i. Fine structure of gene (Seymour Benzer)

ii. One gene one enzyme hypothesis

iii. Genes and related diseases – phenylketonuria, and alkaptonuria

iv. Detection of genetic diseases –amniocentesis Genetic counseling

Unit: 3

Biotechnology:                                                                                                                        (15)

1. Concept of genetic engineering and recombinant DNA technology

2. Restriction endonucleases, their properties and uses

3. Cloning vectors -plasmids and phage vectors

4. Techniques of genetic engineering -isolation of desired gene, gene cloning,

transfer of gene into plants

5. Applications of genetic engineering

*****